MAGIC: AI for Breast Cancer Diagnostics

Breast cancer is the most common form of cancer amongst women and the second leading cause of cancer deaths globally. Population-based organised breast cancer screening is implemented with the overall purpose of reducing mortality through early detection. In Denmark, all women aged 50-69 years are biennially offered mammography screening which is read by at least two expert breast radiologists in accordance with European guidelines. Although double reading is an effective method to reduce missed cancers, it also increases the number of false positives leading to an excess of unnecessary testing and mental distress. Moreover, due to growing demand and a shortage of radiologists, the screening program is very resource demanding.

In recent years, advancements in computer science have presented artificial intelligence (AI) solutions based on novel deep learning (DL) technology as a clinical tool to potentially increase both quality and efficiency of breast cancer screening. DL methods have been tested for numerous applications in breast cancer diagnostics with impressive results in terms of improvement of cancer detection and prediction on mammography in particular as well as reducing false positives. However, all existent studies have tested a DL-based AI system on either a retrospective dataset (mainly single-centre studies) or in limited reader studies, which thereby reduces the generalisability of the results to a real-world clinical setting.

AIM

The objectives of this project are to validate and test an AI system in an existing radiology workflow and analyse the impact on cancer detection and recall rates as well as workload. The project presents the world’s first large-scale validation study and a prospective clinical trial which will assess the impact of a DL-based workflow in Danish clinical screening practice. The project is a multicenter collaboration across all breast cancer screening clinics in the Region of Southern Denmark and includes a complete screening cohort representing almost one-fifth of the entire Danish population in order to obtain a representative sample.

The results of this project are expected to elucidate upon the benefits and feasibility of AI solutions for breast cancer screening in an existing radiology workflow in terms of diagnostic accuracy and workflow efficiency. Most importantly, the project will provide important knowledge on the potential of AI systems in detecting clinically significant cancers which could ultimately improve patient outcome.

PROJECT PERIOD

Start: January 2020
Slut: December 2023

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ABOUT THE PROJECT

The project will – across the hospitals in the Region of Southern Denmark – be the first to test AI for mammography screening images.

PARTNERS

Ole Graumann, Head of Researh, and Benjamin Schnack Rasmussen, Postdoc, from the Department of Radiology at Odense University Hospital Radiologisk Afdeling instituted the project.

The project is a cooperation with the radiology departments at all hospitals in the Region of Southern Denmark.

EXTERNAL FUNDING

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CONTACT

Camilla Stryhn

Camilla Stryhn

Project Manager | (+45) 2361 2333 | [email protected]

Mette Maria Skjøth

Mette Maria Skjøth

Project manager, PhD | (+45) 2057 5043 | [email protected]